谢欣

药理学,细胞生物学

中科院上海药物研究所/国家新药筛选中心

基本信息

第十届中国青年女科学家奖、10多项专利谢欣研究员主要从事基于G蛋白偶联受体（GPCR）的新药发现及干细胞化学生物学研究，聚焦在以下几个方向：　　1、GPCR在重大疾病中的作用及其机制研究，以及药理学干预；　　2、GPCR新药筛选平台的建设及新药发现；　　3、干细胞命运调控小分子的发现、机制研究及在疾病中的应用。

科研成果

总发文数(篇)
0
总被引数(次)
0
H指数
0
篇均被引(次)
0
TOP1%高被引
0
TOP10%高被引
0
FWCI
0
国际合作发文数(篇)
0

成果分析

期刊发文数占比
重点学科匹配度: 论文历年发表情况; 合作发文情况; 文章被引情况

科研论文更多

Synthesis and SAR study of opioid receptor ligands: Mono- and bis-indolomorphinans
- 摘要：
  Mono- and bis-indolomorphinans were synthesized through a multi-step
- 作者：
  Li Fuying;Zhang Ao;Yin Chenlei;Xie Xin;Chen Jie;Liu Jinggen
- 刊名：
  Chemical Biology and Drug Design
- 在线出版时间：
  2009
Glucagon receptor mediates calcium signaling by coupling to Gαq/11 and Gαi/o in HEK293 cells
- 摘要：
  Glucagon induces intracellular Ca²⁺ ([Ca²⁺]i) el
- 作者：
  Xu Yazhen;Xie Xin
- 刊名：
  Journal of Receptors and Signal Transduction
- 在线出版时间：
  2009
[6,7]-Heterocycle-fused 14-hydroxymorphinan derivatives: Design, synthesis, and opioid receptor activity
- 摘要：
  A series of new 14-hydroxymorphinan analogues with a thiazole or imida
- 作者：
  Li Fuying;Zhang Ao;Yin Chenlei;Xie Xin;Chen Jie;Liu Jinggen
- 刊名：
  Chemmedchem
- 在线出版时间：
  2009
Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach
- 摘要：
  The present study describes the identification via privileged structur
- 作者：
  Meng Tao;Peng Hongli;Fang Guanghua;Li Min;Xiong Bing;Zhang Yongliang;Wang Xin;Shen Jingkang;Wang Jue;Xie Xin
- 刊名：
  European Journal of Medicinal Chemistry
- 在线出版时间：
  2010
Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents
- 摘要：
  A novel series of CCR5 antagonists has been identified, utilizing the
- 作者：
  Ben Li;Pei Gang;Jones Eric Dale;Baylis Dean Cameron;Coates Jonathan Alan Victor;Rhodes David Ian;Deadman John Joseph;Zhou Enkun;He Xing;Xie Xin;Li Chen;Yu Shanghai;Wang Miao;Ma Dawei
- 刊名：
  Bioorganic and Medicinal Chemistry Letters
- 在线出版时间：
  2010
Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents
- 摘要：
  Modification of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 re
- 作者：
  Li Ben;Pei Gang;Jones Eric Dale;Baylis Dean Cameron;Coates Jonathan Alan Victor;Rhodes David Ian;Deadman John Joseph;Zhou Enkun;He Xing;Xie Xin;Chen Li;Yu Shanghai;Wang Miao;Ma Dawei
- 刊名：
  Bioorganic and Medicinal Chemistry Letters
- 在线出版时间：
  2010

科创中国

谢欣

基本信息

科研成果

总发文数(篇)

总被引数(次)

H指数

篇均被引(次)

TOP1%高被引

TOP10%高被引

FWCI

国际合作发文数(篇)

成果分析

期刊发文数占比

重点学科匹配度

论文历年发表情况

合作发文情况

文章被引情况

科研论文更多

Synthesis and SAR study of opioid receptor ligands: Mono- and bis-indolomorphinans

Glucagon receptor mediates calcium signaling by coupling to Gαq/11 and Gαi/o in HEK293 cells

[6,7]-Heterocycle-fused 14-hydroxymorphinan derivatives: Design, synthesis, and opioid receptor activity

Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach

Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents

Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents

友情链接

海外专利信息资源系统

省级中心站

科创中国

谢欣

基本信息

科研成果

总发文数(篇)

总被引数(次)

H指数

篇均被引(次)

TOP1%高被引

TOP10%高被引

FWCI

国际合作发文数(篇)

成果分析

期刊发文数占比

重点学科匹配度

论文历年发表情况

合作发文情况

文章被引情况

科研论文 更多

Synthesis and SAR study of opioid receptor ligands: Mono- and bis-indolomorphinans

Glucagon receptor mediates calcium signaling by coupling to Gαq/11 and Gαi/o in HEK293 cells

[6,7]-Heterocycle-fused 14-hydroxymorphinan derivatives: Design, synthesis, and opioid receptor activity

Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach

Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents

Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents

友情链接

海外专利信息资源系统

省级中心站

科研论文更多